Studien

Menopause / Osteoporosis:

• Isoflavone treatment for acute menopausal symptoms.
  Cheng G, Wilczek B, Warner M, Gustafsson JA, Landgren BM.
  Source Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden. guojun.cheng@mednut.ki.se
• Extracted or synthesized soybean Isoflavones reduce menopausal hot flash frequency and severity
  Taku K, Melby MK, Kronenberg F, Kurzer MS, Messina M.
  Source National Institute of Health and Nutrition, Tokyo, Japan.
• Clinical effects of treatment with phytoestrogens in postmenopausal women
  Ciotta L, Stracquadanio M, Pagano I, Andò A, Valenti O, Roccasalva L.
  Source Istituto di Patologia Ostetrica e Ginecologica, Università di Catania, Catania, Italia.
• The pros and cons of plant estrogens for menopause. Isoflavones are effective in treatment of vasomotor symptoms
  Bedell S, Nachtigall M, Naftolin F.
  Department of Obstetrics and Gynecology, New York University School of Medicine, New York 10016, United States
• Effects of standardized phytoestrogen on Taiwanese menopausal women
  Yang TS, Wang SY, Yang YC, Su CH, Lee FK, Chen SC, Tseng CY, Jou HJ, Huang JP, Huang KE.
  Source Department of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan. tsyang@vghtpe.gov.tw
• Soy germ Isoflavones improve menopausal symptoms but have no effect on blood lipids in early postmenopausal women
  Ye YB, Wang ZL, Zhuo SY, Lu W, Liao HF, Verbruggen M, Fang S, Mai HY, Chen YM, Su YX.
  Source Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China.
• Effect of intestinal production of Equol on menopausal symptoms in women treated with soy Isoflavones
  Jou HJ, Wu SC, Chang FW, Ling PY, Chu KS, Wu WH.
  Source Department of Obstetrics and Gynecology, Taiwan Adventist Hospital, Taipei, Taiwan
• Equol improves menopausal symptoms in Japanese women.
  Aso T. // SourceComprehensive Reproductive Medicine, Tokyo Medical University, Tokyo 113-8519, Japan
• S-Equol reduces markers for bone resorption in menopausal women
  The Washington Soy Symposium 2010
• Dietary Equol and bone metabolism in postmenopausal Japanese women
  Ishimi Y.
  Source National Institute of Health and Nutrition, Tokyo 162-8636, Japan. ishimi@nih.go.jp
• Possible role of Equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women
  Wu J, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y.
  SourceNutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan
• A pilot study on the effects of S-equol compared to soy Isoflavones on menopausal hot flash frequency
  Jenks BH, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, Ueno T, Uchiyama S.
  Source Pharmavite LLC, Northridge, CA 91604, USA. bjenks@pharmavite.net
• A Natural S-Equol Supplement Alleviates Hot Flushes and Other Menopausal Symptoms in Equol Nonproducing Postmenopausal Japanese Women
  Takeshi Aso, Shigeto Uchiyama, Yasuhiro Matsumura, Makoto Taguchi, Masahiro Nozaki, Kiyoshi Takamatsu, Bunpei Ishizuka, Toshiro Kubota, Hideki Mizunuma, and Hiroaki Ohta.
  Journal of Women’s Health. January 2012, 21(1): 92-100. doi:10.1089/jwh.2011.2753.
• The clinical importance of the metabolite Equol-a clue to the effectiveness of soy and its Isoflavones.
  Setchell KD, Brown NM, Lydeking-Olsen E.
  SourceClinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, OH 45229, USA. Kenneth.Setchell@chmcc.org
• Impact of dose, frequency of administration, and equol production on efficacy of isoflavones for menopausal hot flashes: a pilot randomized trial
  Crawford SL, Jackson EA, Churchill L, Lampe JW, Leung K, Ockene JK.
  Source From the 1Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts
  Medical School, Worcester, MA; 2Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan
  Medical School, Ann Arbor, MI; and 3Cancer Prevention Program, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA.
• Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials
  Taku K, Melby MK, Kronenberg F, Kurzer MS, Messina M.
  Source National Institute of Health and Nutrition, Tokyo, Japan.
• Estrogen receptor-mediated effects of isoflavone supplementation were not observed in whole-genome gene expression profiles of peripheral blood mononuclear cells in postmenopausal, equol-producing women
  van der Velpen V, Geelen A, Schouten EG, Hollman PC, Afman LA, van ‘t Veer P.
  Source Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. vera.vandervelpen@wur.nl

Cancer prevention:

• Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health.
  Atkinson C, Frankenfeld CL, Lampe JW.
  Source Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4-B402, P.O. Box 19024, Seattle, WA 98109-1024, USA
• Substantial reduction in breast-cancer risk
  Ingram D, Sanders K, Kolybaba M, Lopez D
  University Department of Surgery, Queen Elizabeth II Medical Centre, Perth, Western Australia.
• The chemopreventive action of Equol enantiomers in a chemically induced animal model of breast cancer.
  Brown NM, Belles CA, Lindley SL, Zimmer-Nechemias LD, Zhao X, Witte DP, Kim MO, Setchell KD.
  Source Division of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center 
• Premenopausal Equol excretors show plasma hormone profiles associated with lowered risk of breast cancer.
  Duncan AM, Merz-Demlow BE, Xu X, Phipps WR, Kurzer MS.
  Source Department of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota 55108, USA
• Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to Daidzein-metabolizing phenotypes among premenopausal women in the United States.
  Atkinson C, Newton KM, Bowles EJ, Yong M, Lampe JW.
  Source Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
• Premenopausal Equol Excretors Show Plasma Hormone Profiles Associated with Lowered Risk of Breast Cancer
  Alison M. Duncan, Barbara E. Merz-Demlow, Xia Xu, William R. Phipps, and Mindy S. Kurzer
•  The chemopreventive action of Equol enantiomers in a chemically induced animal model of breast cancer
  Nadine M. Brown, Carrie A. Belles, Stephanie L. Lindley, Linda D. Zimmer-Nechemias, Xueheng Zhao, David P. Witte, Mi-Ok Kim,1 and Kenneth D.R. Setchell
• Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence
  Trent D Lund,1 Crystal Blake,2 Lihong Bu,3 Amy N Hamaker,2 and Edwin D Lephart
• Relations between prostate cancer incidence and Equol, one of soy Isoflavones
  G. Japan Prostate Cancer Prevention Study Group, H. Akaza
• Equol Is a Novel Anti-Androgen that Inhibits Prostate Growth and Hormone Feedback
  Trent D. Lund2, 3 , Daniel J. Munson 3 , Megan E. Haldy 3 , Kenneth D.R. Setchell 4 , Edwin D. Lephart 5 and Robert J. Handa
• Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer?
  Bosviel R, Dumollard E, Déchelotte P, Bignon YJ, Bernard-Gallon D.
  Source Centre Jean Perrin, Département d’Oncogénétique, CBRV, Clermont-Ferrand, France.
• Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast cancer cell lines
  Bosviel R, Durif J, Déchelotte P, Bignon YJ, Bernard-Gallon D.
  Source Centre Jean Perrin, Département d’Oncogénétique, CBRV, 28 Place Henri Dunant, Clermont-Ferrand, France.
• Equol inhibits the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2
  Magee PJ, Allsopp P, Samaletdin A, Rowland IR.
  Source School of Biomedical Sciences, Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, Northern Ireland, pj.magee@ulster.ac.uk.
• Equol enhances tamoxifen’s anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells
  Charalambous C, Pitta CA, Constantinou AI.
  Source Department of Biological Sciences, University of Cyprus, 75 Kallipoleos str, PO box 20537, Lefkosia 1678, Cyprus.
• Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines
  Dagdemir A, Durif J, Ngollo M, Bignon YJ, Bernard-Gallon D.
  Source Centre Jean Perrin, Département d’Oncogénétique, CBRV, Clermont-Ferrand, France.

Anti Aging:

• The effects of natural S-equol supplementation on skin aging in postmenopausal women
  Oyama A, Ueno T, Uchiyama S, Aihara T, Miyake A, Kondo S, Matsunaga K.
  Source Saga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, Saga, Japan. a_oyama@research.otsuka.co.jp
• Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells
  Roles for F-Actin and GPR30
  David J. Rowlands, Sarah Chapple, Richard C.M. Siow, and Giovanni E. Mann
• Protective effects of equol and their polyphenolic isomers against dermal aging
  Source Lephart ED.Department of Physiology, Developmental Biology and the Neuroscience Center, Brigham Young University , Provo, UT , USA.
• Photoimmune protective effect of the phytoestrogenic isoflavonoid equol is partially due to its antioxidant activities.
  Widyarini S, Domanski D, Painter N, Reeve VE.
  Source Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia.
• Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen.
  Widyarini S, Husband AJ, Reeve VE.
  Source Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.