Recent study overviews:

Menopause / Osteoporosis:


Isoflavone treatment for acute menopausal symptoms.
Cheng G, Wilczek B, Warner M, Gustafsson JA, Landgren BM.
SourceDepartment of Biosciences and Nutrition, Karolinska Institutet, Novum, Huddinge, Sweden.

Extracted or synthesized soybean Isoflavones reduce menopausal hot flash frequency and severity
Taku K, Melby MK, Kronenberg F, Kurzer MS, Messina M.
SourceNational Institute of Health and Nutrition, Tokyo, Japan.

Clinical effects of treatment with phytoestrogens in postmenopausal women
Ciotta L, Stracquadanio M, Pagano I, Andò A, Valenti O, Roccasalva L.
SourceIstituto di Patologia Ostetrica e Ginecologica, Università di Catania, Catania, Italia.

The pros and cons of plant estrogens for menopause. Isoflavones are effective in treatment of vasomotor symptoms
Bedell S, Nachtigall M, Naftolin F.
Department of Obstetrics and Gynecology, New York University School of Medicine, New York 10016, United States

Effects of standardized phytoestrogen on Taiwanese menopausal women
Yang TS, Wang SY, Yang YC, Su CH, Lee FK, Chen SC, Tseng CY, Jou HJ, Huang JP, Huang KE.
SourceDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan.
Soy germ Isoflavones improve menopausal symptoms but have no effect on blood lipids in early postmenopausal women
Ye YB, Wang ZL, Zhuo SY, Lu W, Liao HF, Verbruggen M, Fang S, Mai HY, Chen YM, Su YX.
SourceGuangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, People’s Republic of China.

Effect of intestinal production of Equol on menopausal symptoms in women treated with soy Isoflavones
Jou HJ, Wu SC, Chang FW, Ling PY, Chu KS, Wu WH.
SourceDepartment of Obstetrics and Gynecology, Taiwan Adventist Hospital, Taipei, Taiwan

Equol improves menopausal symptoms in Japanese women.
Aso T. // SourceComprehensive Reproductive Medicine, Tokyo Medical University, Tokyo 113-8519, Japan

S-Equol reduces markers for bone resorption in menopausal women
The Washington Soy Symposium 2010

Dietary Equol and bone metabolism in postmenopausal Japanese women
Ishimi Y.
SourceNational Institute of Health and Nutrition, Tokyo 162-8636, Japan.
Possible role of Equol status in the effects of isoflavone on bone and fat mass in postmenopausal Japanese women
Wu J, Oka J, Ezaki J, Ohtomo T, Ueno T, Uchiyama S, Toda T, Uehara M, Ishimi Y.
SourceNutritional Epidemiology Program, National Institute of Health and Nutrition, Tokyo, Japan

A pilot study on the effects of S-equol compared to soy Isoflavones on menopausal hot flash frequency
Jenks BH, Iwashita S, Nakagawa Y, Ragland K, Lee J, Carson WH, Ueno T, Uchiyama S.
SourcePharmavite LLC, Northridge, CA 91604, USA.
A Natural S-Equol Supplement Alleviates Hot Flushes and Other Menopausal Symptoms in Equol Nonproducing Postmenopausal Japanese Women
Takeshi Aso, Shigeto Uchiyama, Yasuhiro Matsumura, Makoto Taguchi, Masahiro Nozaki, Kiyoshi Takamatsu, Bunpei Ishizuka, Toshiro Kubota, Hideki Mizunuma, and Hiroaki Ohta. Journal of Women’s Health. January 2012, 21(1): 92-100. doi:10.1089/jwh.2011.2753.

The clinical importance of the metabolite Equol-a clue to the effectiveness of soy and its Isoflavones.
Setchell KD, Brown NM, Lydeking-Olsen E.
SourceClinical Mass Spectrometry, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, OH 45229, USA.
Impact of dose, frequency of administration, and equol production on efficacy of isoflavones for menopausal hot flashes: a pilot randomized trial
Crawford SL, Jackson EA, Churchill L, Lampe JW, Leung K, Ockene JK.
Source From the 1Division of Preventive and Behavioral Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA; 2Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI; and 3Cancer Prevention Program, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA.

Extracted or synthesized soybean isoflavones reduce menopausal hot flash frequency and severity: systematic review and meta-analysis of randomized controlled trials
Taku K, Melby MK, Kronenberg F, Kurzer MS, Messina M.
Source National Institute of Health and Nutrition, Tokyo, Japan.

Estrogen receptor-mediated effects of isoflavone supplementation were not observed in whole-genome gene expression profiles of peripheral blood mononuclear cells in postmenopausal, equol-producing women
van der Velpen V, Geelen A, Schouten EG, Hollman PC, Afman LA, van ‘t Veer P.
Source Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.

Cancer prevention:


Gut bacterial metabolism of the soy isoflavone daidzein: exploring the relevance to human health.
Atkinson C, Frankenfeld CL, Lampe JW.
SourceFred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, M4-B402, P.O. Box 19024, Seattle, WA 98109-1024, USA

substantial reduction in breast-cancer risk
Ingram D, Sanders K, Kolybaba M, Lopez D
University Department of Surgery, Queen Elizabeth II Medical Centre, Perth, Western Australia.

The chemopreventive action of Equol enantiomers in a chemically induced animal model of breast cancer.
Brown NM, Belles CA, Lindley SL, Zimmer-Nechemias LD, Zhao X, Witte DP, Kim MO, Setchell KD.
SourceDivision of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital Medical Center

Premenopausal Equol excretors show plasma hormone profiles associated with lowered risk of breast cancer.
Duncan AM, Merz-Demlow BE, Xu X, Phipps WR, Kurzer MS.
SourceDepartment of Food Science and Nutrition, University of Minnesota, St. Paul, Minnesota 55108, USA

Demographic, anthropometric, and lifestyle factors and dietary intakes in relation to Daidzein-metabolizing phenotypes among premenopausal women in the United States.
Atkinson C, Newton KM, Bowles EJ, Yong M, Lampe JW.
SourceDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA

Premenopausal Equol Excretors Show Plasma Hormone Profiles Associated with Lowered Risk of Breast Cancer
Alison M. Duncan, Barbara E. Merz-Demlow, Xia Xu, William R. Phipps, and Mindy S. Kurzer

The chemopreventive action of Equol enantiomers in a chemically induced animal model of breast cancer
Nadine M. Brown, Carrie A. Belles, Stephanie L. Lindley, Linda D. Zimmer-Nechemias, Xueheng Zhao, David P. Witte, Mi-Ok Kim,1 and Kenneth D.R. Setchell

Equol an isoflavonoid: potential for improved prostate health, in vitro and in vivo evidence
Trent D Lund,1 Crystal Blake,2 Lihong Bu,3 Amy N Hamaker,2 and Edwin D Lephart

Relations between prostate cancer incidence and Equol, one of soy Isoflavones
G. Japan Prostate Cancer Prevention Study Group, H. Akaza

Equol Is a Novel Anti-Androgen that Inhibits Prostate Growth and Hormone Feedback
Trent D. Lund2, 3 , Daniel J. Munson 3 , Megan E. Haldy 3 , Kenneth D.R. Setchell 4 , Edwin D. Lephart 5 and Robert J. Handa

Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer?
Bosviel R, Dumollard E, Déchelotte P, Bignon YJ, Bernard-Gallon D.
Source Centre Jean Perrin, Département d’Oncogénétique, CBRV, Clermont-Ferrand, France.

Epigenetic modulation of BRCA1 and BRCA2 gene expression by equol in breast cancer cell lines
Bosviel R, Durif J, Déchelotte P, Bignon YJ, Bernard-Gallon D.
Source Centre Jean Perrin, Département d’Oncogénétique, CBRV, 28 Place Henri Dunant, Clermont-Ferrand, France.

Equol inhibits the invasion of MDA-MB-231 breast cancer cells potentially via the down-regulation of matrix metalloproteinase-2
Magee PJ, Allsopp P, Samaletdin A, Rowland IR.
Source School of Biomedical Sciences, Northern Ireland Centre for Food and Health, University of Ulster, Coleraine, BT52 1SA, Northern Ireland,
Equol enhances tamoxifen’s anti-tumor activity by induction of caspase-mediated apoptosis in MCF-7 breast cancer cells
Charalambous C, Pitta CA, Constantinou AI.
Source Department of Biological Sciences, University of Cyprus, 75 Kallipoleos str, PO box 20537, Lefkosia 1678, Cyprus.

Histone lysine trimethylation or acetylation can be modulated by phytoestrogen, estrogen or anti-HDAC in breast cancer cell lines
Dagdemir A, Durif J, Ngollo M, Bignon YJ, Bernard-Gallon D.
Source Centre Jean Perrin, Département d’Oncogénétique, CBRV, Clermont-Ferrand, France.


Anti Aging:


The effects of natural S-equol supplementation on skin aging in postmenopausal women
Oyama A, Ueno T, Uchiyama S, Aihara T, Miyake A, Kondo S, Matsunaga K.
SourceSaga Nutraceuticals Research Institute, Otsuka Pharmaceutical Co., Ltd, Saga, Japan.
Equol-Stimulated Mitochondrial Reactive Oxygen Species Activate Endothelial Nitric Oxide Synthase and Redox Signaling in Endothelial Cells
Roles for F-Actin and GPR30
David J. Rowlands, Sarah Chapple, Richard C.M. Siow, and Giovanni E. Mann

Protective effects of equol and their polyphenolic isomers against dermal aging
Source Lephart ED.Department of Physiology, Developmental Biology and the Neuroscience Center, Brigham Young University , Provo, UT , USA.

Photoimmune protective effect of the phytoestrogenic isoflavonoid equol is partially due to its antioxidant activities.
Widyarini S, Domanski D, Painter N, Reeve VE.
Source Faculty of Veterinary Science, University of Sydney, Sydney, NSW 2006, Australia.

Protective effect of the isoflavonoid equol against hairless mouse skin carcinogenesis induced by UV radiation alone or with a chemical cocarcinogen.
Widyarini S, Husband AJ, Reeve VE.
Source Faculty of Veterinary Science, University of Sydney, NSW 2006, Australia.